Dr. P. Venkataraman

Assistant Professor

Area: Medical Research, Biochemistry, Endocrinology
Affiliation: Department of Medical Research, Kattankulathur Campus, SRM Institute of Science and Technology
Email: venkataraman.p@ktr.srmuniv.ac.in

Education

Ph.D Endocrinology University of Madras, 2009
M.Phil Endocrinology University of Madras, 2002
P.G.Diploma Medical Laboratory Technology  Loyola Institute of Vocational Education (LIVE), Chennai, 2001
M.Sc Biochemistry University of Madras, 2000

Other Details

Courses

  • Research Methodology,
  • Clinical Research,
  • Physiology

Research Interests

  • Diabetes Mellitus,
  • Neurodegeneration,
  • Amyloid pathology,
  • Immune system,
  • Kidney and Respiratory diseases,
  • Environmental toxicology 

Selected Publications

  • Vinothkumar G, Krishnakumar S, Sureshkumar,  Shivashekar G, Sreedhar S, Preethikrishnan, Dinesh S, Sundaram A, Balakrishnan D, Riya, Venkataraman P (2018). Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and Aβ expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer's disease: A pilot study. Biomedicine & Pharmacotherapy, 104:211-222
  • Nirmala A, Venkataraman P, Kanniammal C, Rani Anitha, Arulappan  Judie (2018). Prevalence of Obesity and Associated Risk Factors among Adolescents in Kancheepuram, South India. International Journal of Nursing Education, 10 (1); 55-60.
  • VPR Sivakumar, Balakrishnan Doraisami, Venkataraman Prabhu, Ponmathi Paramanandam (2018). Age Related Timed Up and Go Test Values and Its Analysis among Elderly Kancheepuram District Population. Journal of Clinical and Diagnostic Research, Vol-12(10):YC05-YC07.
  • Nirmala A, Venkataraman P,  Kanniammal C, Judie A, Lakshmi E (2018). Dietary Patterns and Association with Socio Economic, Lifestyle Characteristics and Nutritional Status among Adolescents with Obesity in Selected Schools, Kancheepuram, South India. International Journal of Nursing Education, 10 (3); 71-76.
  • Nirmala A, Kanniammal C, Venkataraman P, Judie Arulappan (2018). Predisposing factors associated with obesity among adolescents-A case control study. Biomedical Research, 29 (18): 3497-3501.
  • Vinothkumar G, Kedharnath C, Krishnakumar S, Sreedhar S, Preethikrishnan, Dinesh S, Sundaram A, Balakrishnan D, Shivashekar G, Sureshkumar,  Venkataraman P (2017). Abnormal amyloid β42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease. BBA Clinical, 8, 20-27.
  • Sivakumar Annamalai, Lavanya Mohanam, Veena Raja, Alwin Dev, Venkataraman Prabhu (2017). Antiobesity, antioxidant and hepatoprotective effects of Diallyl trisulphide (DATS) alone or in combination with Orlistat on HFD induced obese rats. Biomedicine & Pharmacotherapy, 93, 81–87.
  • Ganesan A, Mini Jacob S, Arvind Selvin Kumar R, Padmaraj R, Anandan B,   Sambantham S, Balakrishnan D, Sundaram A, Venkataraman P (2017). Identification of functional snps of MDR1 gene among nephrotic syndrome children in south India. Asian J Pharm Clin Res, 10 (2): 418-422.
  • Karthick N, Poornima KN, Saravanan A, Alwin D, Venkataraman P (2016). Phosphorylation of tau proteinin brain regions of chronic renal failure induced rats: Ameliorative effect of erythropoietin. Asian J Pharm Clin Res, 9 (3): 392-397. 
  • Sivakumar Annamalai, Lavanya Mohanam, D. Alwin, Venkataraman Prabhu (2016). Effect of combination therapy of melatonin and orlistat on high fat diet induced changes in lipid profiles and liver function parameters in serum of rats. Obesity Medicine, 2, 41-45.
  • Sureshbabu BV, Gunasekaran P, Venkataraman P, Kaveri K (2016). Prevalence and Molecular characterization of Circulating Respiratory Syncytial Virus (RSV) in Chennai, South India. Biosciences Biotechnology Research Asia, 13 (2), 1055-1062.
  • Karthick N, Alwin D, Poornima KN, Chitra V, Saravanan A, Balakrishnan D, Venkataraman P (2015). Neurobehavioral alterations and brain creatine kinase system changes in chronic renal failure induced male wistar rats: Impact of Erythropoietin supplementation. J Bioequiv Bioavailab, 7 (2): 074 - 081.
  • Kavitha D, Anjalakshi C, Venkataraman P, Rukumani J, Murali (2015). Knowledge, Attitude and practice regarding Vitamin D deficiency among antenatal mothers in Tamilnadu. Int J Pharm Biosci,6(4); (B) 486-497.
  • Balakrishnan D, Rajesh MP, Venkataraman P, Purushoth E, Darshan BS, Chandraprabha N (2014). Occurrence of perchlortae in various water sources in south India. J Environ Science & Engg. 56(2), 147-152.
  • Selvakumar K, Bavithra S, Krishnamoorthy G, Ganesh A, Venkataraman P, Arunakaran J (2013). Impact of quercetin on PCB (aroclor 1254) induced impairment of  dopaminergic receptors expression in hippocampus of adult male wistar rats. Biomed Prevent Nutr, 3, 42-52.
  • Selvakumar K, Krishnamoorthy G, Venkataraman P, Arunakaran J (2013). Reactive oxygen species induced oxidative stress, neuronal apoptosis and alternative death pathways. Advances in Bioscience and Biotechnology,4, 14-21.
  • Krishnamoorthy G, Selvakumar K, Venkataraman P, Elumalai P, Arunakaran J (2013). Lycopene supplementation prevents reactive oxygen species mediated apoptosis in sertoli cells of adult albino rats exposed to polychlorinated biphenyls. Interdiscip Toxicol, 6 (2), 83-92.
  • Bavithra S, Selvakumar K, Krishnamoorthy G, Venkataraman P, Arunakaran J (2013). Melatonin attenuates polychlorinated biphenyls induced apoptosis in the neuronal cells of cerebral cortex and cerebellum of adult male rats – in vitro. Environmental Toxicol Pharmacol, 36, 152-163.
  • Selvakumar K, Bavithra S, Ganesh L, Krishnamoorthy G, Venkataraman P, Arunakaran J (2013). Polychlorinated biphenyls induced oxidative stress mediated neurodegeneration in hippocampus and behavioral changes of adult rats: Anxiolytic -like effects of quercetin. Toxicol Lett, 222, 45-54.
  • Selvakumar K, Bavithra S, Suganthi M, Benson CS, Elumalai P, Arunkumar R, Krishnamoorthy G, Venkataraman P, Arunakaran J (2012). Protective Role of Quercetin on PCBs-Induced Oxidative Stress and Apoptosis in Hippocampus of Adult Rats. Neurochemical Research, 37, 708-721. (DOI 10.1007/s11064-011-0661-5).
  • Bavithra S, Selvakumar K, Pradeepa Kumari R, Krishnamoorhty G, Venkataraman P, Arunakaran J (2012). Polychlorinated biphenyls (PCBs) induced oxidative stress plays a critical role on cerebellar dopaminergic receptor expression: Ameliorative role of quercetin. Neurotoxicity research.21, 149-159. (Neurotox Res DOI 10.1007/s12640-011-9253- z.
  • Selvakumar K, Sheerin Banu L, Krishnamoorthy G, Venkataraman P, Elumalai P, Arunakaran J (2011). Differential expression of androgen and estrogen receptors in PCB (Aroclor 1254)-exposed rat ventral prostate: Impact of alpha-tocopherol. Exp. Toxicol. Pathol. 63, 105 -112.
  • Krishnamoorthy G, Selvakumar K, Elumalai P, Venkataraman P, Arunakaran J. Protective role of lycopene on polychlorinated biphenyls (Aroclor 1254)- induced adult rat Sertoli cell dysfunction by increased oxidative stress and endocrine disruption (2011) Biomed Prevent Nutr. 1; 116-125.
  • Selvakumar K, Bavithra S, Krishnamoorthy G, Venkataraman P, Arunakaran J (2011). Polychlorinated biphenyls (PCBs)- induced oxidative stress on rat hippocampus: A neuroprotective role of quercetin. The Scientific World Journal. Volume 2012, Article ID 980314, 1-10, doi:10.1100/2012/980314.
  • Venkataraman P, Selvakumar K, Krishnamoorthy G, Muthusami S, Rameshkumar R, Prakash S, Arunakaran J (2010). Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci. Res 66; 189-197.
  • Elumalai P, Krishnamoorthy G, Selvakumar K, Arunkumar R, Venkataraman P, Arunakaran J (2009). Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Reprod Toxicol, 27 (1), 41-45.
  • Venkataraman P, Krishnamoorthy G, Selvakumar K, Arunakaran J (2009). Oxidative stress alters creatine kinase system in serum and brain regions of PCB (Aroclor 1254) exposed rats: Protective role of melatonin. Basic and Clinical Pharmacology and Toxicology 105; 92 – 97.
  • Venkataraman P, Krishnamoorthy G, Vengatesh G, Srinivasan N, Aruldhas MM, Arunakaran J (2008). Protective role of melatonin on PCB (Aroclor 1254) induced oxidative stress and changes in membrane bound ATPases and acetylcholine esterase in cerebellum, cerebral cortex and hippocampus of adult rat brain. Int J Dev Neurosci 26; 585-591.
  • Krishnamoorthy G, Venkataraman P, Arunkumar A, Vignesh RC, Aruldhas MM, Arunakaran J (2007).  Ameliorative effect of vitamins (alpha-tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm. Reprod Toxicol. 23(2):239-245.
  • Sridevi N, Venkataraman P, Senthilkumar K, Krishnamoorthy G, Arunakaran J (2007). Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: protective role of alpha-tocopherol. Biomed Pharmacotherab 61, 435-440.
  • Rajeswary S, Kumaran B, Ilangovan R, Yuvaraj S, Sridhar M, Venkataraman P, Srinivasan N, Aruldhas MM. Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats. Reprod Toxicol. 2007, 24(3-4):371-80.
  • Kanagaraj P, Vijayababu MR, Ilangovan R, Senthilkumar K, Venkataraman P, Aruldhas MM, Arunakaran J.Effect of 17beta-estradiol on apoptosis, IGF system components and gelatinases A and B in prostate cancer cells (PC-3). Clin Chim Acta. 2007, 377(1-2):70-8.
  • Venkataraman P, Muthuvel R, Krishnamoorthy G, Arunkumar A, Sridhar M,   Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran  J (2007). PCB (aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. NeuroToxicology 28 (3): 490-498.
  • Arunkumar A, Vijayababu MR, Venkataraman P, Senthilkumar K, Arunakaran J. Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic. Biol Pharm Bull 2006, 29 (2): 375-379.
  • Banudevi S, Krishnamoorthy G, Venkataraman P, Vignesh RC, Aruldhas MM and Arunakaran J (2006). Role of ά-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food Chem  Toxicol  44:2040-2046.
  • Muthuvel R, Venkataraman P, Krishnamoorthy G, Gunadharini DN,  Kanagaraj P, Jone Stanley A, Srinivasan N, Balasubramanian K, Aruldhas MM,  Arunakaran J. (2006). Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rats. Clin Chim Acta 365: 297-303.
  • Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem. 2006, 287(1-2):109-16.
  • Senthilkumar K, Arunkumar A, Sridevi N, Vijayababu MR, Kanagaraj P, Venkataraman P, Aruldhas MM, Srinivasan N, Arunakaran J (2006). Chemoprevention of MNU and testosterone induced prostate carcinogenesis by calcitriol (vitamin D3) in adult male albino wistar rats. Ann Cancer Res Therap 14: 12-18.
  • Krishnamoorthy G, Murugesan P, Muthuvel R, Gunadharini DN, Vijayababu MR, Arunkumar A, Venkataraman P, Aruldhas MM, Arunakaran J. Effect of Aroclor 1254 on Sertoli cellular antioxidant system, androgen binding protein and lactate in adult rat in vitro. Toxicology. 2005, 212(2-3):195-205.
  • Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, Subramaniam V, Jagadeesan A, Narasimhan S.Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta. 2005, 360(1-2):81-6.
  • Venkataraman P, Sridhar M, Dhanammal S, Vijayababu MR, Srinivasan N, Arunakaran J (2004b). Antioxidant role of zinc in PCB (Aroclor 1254) exposed ventral prostate of albino rats. J Nutr Biochem 15(10), 608-613.
  • Venkataraman P, Sridhar M, Sivadanammal, Vijaya Babu MR, Arunkaran A, Srinivasan N and Arunakaran J (2004a). Effect of vitamins supplementation on PCB (Aroclor 1254) induced changes in ventral prostatic androgen and estrogen receptors. Endocr. Res. 30: 469-480. (Pubmed Indexed, IF 0.7)
  • Sridhar M, Venkataraman P, Dhanammal S, Arunkumar A, Aruldhas MM, Srinivasan N, Arunakaran J. Impact of polychlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate. Asian J Androl. 2004, 6(1):19-22.

Papers Presented

  • Venkataraman P, Karthick N, “Impact of rHu-Epo supplementation on CRF induced Neurobehavioral changes in rats: Studies on correlation with APP ratio, β amyloid and pTau expression”, in 5th World congress on Bioavailability and Bioequivalence: Pharmaceutical R&D Summit (BABE), Baltimore, Maryland, USA, 2014.
  • Venkataraman P, Balakrishnan D, “Definition of community burden of perchlorate in clean water”, in 1st international conference on emerging technologies in clean water, Department of chemistry, IIT Madras, 2012.
  • Venkataraman P, Balakrishnan D, “A logical aetiology for hypothyroidism in plains”, in 2nd International symposium on Mass Spectrometry in Life sciences, NCBS, Bengaluru, 2011.
  • Venkataraman P, Arunakaran J, “Effect of Melatonin on PCB induced β amyloid protein and histomorphological changes in rat brain regions”, in SRBCE, University of Hyderabad, 2009.
  • Venkataraman P, Arunakaran J, “Impact of melatonin on creatine kinase system in PCB induced rat brain regions”, in SRBCE, University of Kerala, Trivandrum, 2007.
  • Venkataraman P, Arunakaran J, “Protective role of melatonin on chronic PCB induced Neurotoxicity”, in Trends and techniques in Molecular Neuroendocrinology (Workshop cup symposium), University of Hyderabad, 2006.
  • Venkataraman P, Arunakaran J, “Effect of melatonin on acute PCB induced oxidative stress, ATPases and acetyl cholinesterase activities in rat brain regions”, in SRBCE, IIT Roorkee, 2006.
  • Venkataraman P, Arunakaran J, “Effect of vitamin C on PCB induced oxidative stress in cerebellum and cerebral cortex of albino rats”, in SRBCE, Visva Bharati University, Santineketan, West Bengal, 2005.
  • Venkataraman P, Arunakaran J, “Antioxidant role of zinc on PCB induced oxidative stress in rat ventral prostate”, in SRBCE, University of Madras, 2004.
  • Venkataraman P, Arunakaran J, “Effect of vitamin C, E and Quercetin on PCB induced oxidative stress in ventral prostate of rat”, in SRBCE, Banaras Hindu University, Varanasi, 2003.

Working Papers

  • Expression levels of Obesity related genes in high fat diet (HFD) induced experimental animals 
  • Polymorphism of selected genes in Nephrotic syndrome children, South Indian population
  • Anticancer activity of Calotropis Gigantea on cancer cell lines

Work in Progress

  • Nurse-Led program and Obesity
  • Platelet protein abnormalities in Chronic kidney disease patients with Cognitive dysfunction

Academic Experience

  • Tutor, Department of Physiology, SRM Medical college Hospital and Research Centre, Kattankulathur, Tamilnadu, India (2008 to 2009).
  • Assistant Professor, Department of Medical Research, SRM Medical college Hospital and Research Centre, Kattankulathur, Tamilnadu, India (2009 to till date).

PhD Guideship:

  • PhD awarded – 2
  • PhD synopsis submitted – 1
  • Ongoing students – 5

Achievements and Awards

  • Delivered prestigious Keynote address and Recruited as a Co Chair person in one entire scientific session in, “5th World congress on Bioavailability and Bioequivalence: Pharmaceutical R&D Summit”, held in Baltimore, Maryland, USA, 2014. DST –SERB and Indian National Science Academy (INSA) sponsored all the expenditures for participation.
  • Resource person & conducted the practical session in DST, DBT, ICMR, CSIR and UNOM funded workshop entitled, “National workshop on Techniques in Molecular and Cellular Endocrinology”, organized by the Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani campus, University of Madras, January 2010 & March 2013.
  • Presented prestigious guest lecture in “One day seminar on Research Methodology”, on December 2016 in Meenakshi Academy of Higher Education and Research (MAHER), Chennai.
  • Appreciated by SRM IST for research activities and publications in “Teacher’s day 2011, 2012 & 2015” celebrations.
  • As a Principal Investigator, completed the research project entitled, “Effect of erythropoietin on platelet amyloidogenic pathway and serum inflammatory molecules in patients with CKD: Biochemical and Molecular study” – funded by ICMR, New Delhi, 2014.
  • As a Principal Investigator, completed the research project entitled, “Impact of melatonin and DATS supplementation on obesity related genes in HFD induced rats” – funded by SRM IST, “Under the selective excellence research program”, 2016.
  • As Co Principal Investigator in Ongoing project entitled, “Regulation of parathyroid hormone stimulation of matrix metalloproteinase-13 expression in osteoblastic cells by MicroRNAs”, - funded by DBT, New Delhi, 2016.

Memberships

 

  • Indian Science Congress association, 2011.

 

 

 

 

 

 

 

 

 

 

 

 

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