Dr. S. Mannathan

M.Sc, Ph.D

Assistant Professor (DST-Inspire)

S. Mannathan was born in Kuruvinatham, Pondicherry, India in 1983. He completed his B. Sc. and M. Sc. in Chemistry at St. Joseph’s college of arts and science, Cuddalore (Tamilnadu), India. He obtained his Ph.D. in 2011 at National Tsing Hua University, Hsinchu, Taiwan, under the supervision of Professor Chien-Hong Cheng. Later, he moved to University of Groningen, The Netherlands and worked as postdoc under the guidance of Prof. Adrian Minnaard and Prof. Johannes G. de Vries. Currently, he is working as Assistant professor (DST-Inspire) in SRM University, Kattankulathur, Tamilnadu. 

  • Metal-Catalyzed Organic Transformation Reactions
  •  Asymmetric Synthesis
  • Cross-Coupling and Multicomponent Reactions

Yet to be explored

  • S. Mannathan, S. Raoufmoghaddam, J. N. H. Reek, J. G. de Vries, A. J. Minnaard, “Enantioselective Intramolecular Reductive Heck Reaction with a Palladium/Monodentate Phosphoramidite Catalyst” Chem. Cat. Chem. 2016, accepted (IF = 4.72)
  • R. Santhoshkumar, S. Mannathan, C.-H. Cheng, “Ligand-Controlled Divergent C−H Functionalization of Aldehydes with Enynes by Cobalt Catalysts, J. Am. Chem. Soc., 2015, 137, 16116-16120 (IF = 13.03)
  • S. Mannathan, S. Raoufmoghaddam, J. N. H. Reek, J. G. de Vries, A. J. Minnaard, " Palladium(II) Acetate Catalyzed Reductive Heck reaction of Enones; a Practical Approach," Chem. Cat. Chem. 2015, 7, 3923-3927 (IF = 4.72)
  • S. Raoufmoghaddam, S. Mannathan, A. J. Minnaard, J. G. de Vries, J. N. H. Reek, “Pd(0)–NHC Catalyzed Reductive Heck Reaction of Enones: A detailed Mechanistic Study” Chem. Eur. J. 2015, 21, 18811-18820 (IF = 5.77)
  • R. Santhoshkumar, S. Mannathan, C.-H. Cheng, “Cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters via C-H activation” Org. Lett., 2014, 16, 4208 – 4211 (IF = 6.73)
  • Y.-C. Hong, P. Gandeepan, S. Mannathan, W.-T. Lee, C.-H. Cheng, “Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers”, Org. Lett., 2014, 16, 2806–2809 (IF = 6.73)
  • S. Mannathan, C.-H. Cheng, [4+2] vs [3+2] Annulations in the Nickel- and Cobalt-Catalyzed Reaction of ortho-Haloimines with Alkynes: Differential Reactivity towards the Synthesis of Isoquinolines and Aminoindenes”, J. Chin. Chem. Soc. 2014, 61, 59-66 (Special Issue for the 60th Anniversary of Journal of the Chinese Chemical Society –Invited Mini review) (IF = 0.85)
  • C.-H. Yeh, Y.-C. Lin, S. Mannathan, K. Hung, C.-H. Cheng, “Ene-Carbonyl Reductive Coupling for the Synthesis of 3,3-Disubstituted Phthalide, 3-Hydroxyisoindolin-1-one and 3-Hydroxyoxindole Derivatives”, Adv. Synth. Catal. 2014, 356, 831 – 842 (IF = 6.45)
  • S. Mannathan, C.-H. Cheng, " Nickel-Catalyzed Regio- and Stereoselective Reductive Coupling of Oxa- and Azabicyclic Alkenes with Enones and Electron-Rich Alkynes (also the cover picture for the issue, Adv. Synth. Catal. 2014, 356 (10), 2125), Adv. Synth. Catal. 2014, 356, 2239 (IF = 6.45)
  • C.-M. Yang, S. Mannathan and C.-H. Cheng, “Nickel-catalyzed chemo- and stereoselective alkenylative cyclization of 1,6-enynes with alkenylboronic acids” Chem. Eur. J. 2013, 19, 12212 – 12216 (IF = 5.77)
  • S. Mannathan, C.-H. Cheng, Nickel-catalyzed regio- and diastereoselective intermolecular three-component coupling of oxabicyclic alkenes with alkynes and organoboronic acids, Chem.Commun. 2013, 49, 1557 (IF = 6.56)
  • M.-H. Chen, S. Mannathan, P.-S. Lin and C.-H. Cheng, “Cobalt(II)-Catalyzed 1,4-addition of Organoboronic Acids to Activated Alkenes: An Application to Highly cis-Stereoselective Synthesis of Aminoindane Carboxylic Acid Derivatives (VIP-Paper)” Chem. Eur. J. 2012, 18, 4948 (IF = 5.77)
  • C.-H. Wei, S. Mannathan, and C.-H. Cheng, Regio- and Enantioselective Cobalt-Catalyzed Reductive [3+2] Cycloaddition Reaction of Alkynes with Cyclic Ketones: A Route to Bicyclic Tertiary Alcohols, Angew. Chem. Int. Ed. 2012, 51, 10592 (IF = 11.70)
  • S. Mannathan and C.-H. Cheng, “Synthesis of trans-Disubstituted Alkenes by Cobalt‑Catalyzed Reductive Coupling of Terminal Alkynes with Activated Alkenes” Chem. Eur. J. 2012, 18, 11771 (IF = 5.77)
  • C.H. Wei, S. Mannathan and C.-H. Cheng, Enantioselective Synthesis of β-Substituted Cyclic Ketones via Cobalt-Catalyzed Asymmetric Reductive Coupling of Alkynes with Alkenes, J. Am. Chem. Soc., 2011, 133, 6942. (IF = 13.03)
  • S. Mannathan and C.-H. Cheng, Cobalt-Catalyzed Regio- and Stereoselective Intermolecular Enyne Coupling: an Efficient Route to 1,3-Diene Derivatives, Chem commun. 2010, 46, 1923 (IF = 6.56)
  • S. Mannathan, M. Jeganmohan and C.-H. Cheng, Nickel-Catalyzed Borylative Coupling of Alkynes with Enones and Bis(pinacolato)diboron: A Novel Route to Substituted Alkenylboronates, Angew. Chem. Int. Ed. 2009, 48, 2192 (IF = 11.70)

 Allied Chemistry II - UCY15461

  • Applications are invited for one JRF position under the DST-Inspire project entitled " Metal-Catalyzed New Cross Coupling Reactions”
  • The position is purely temporary and will be funded by DST project. The selected candidate will work in the Research Institute, SRM University, Kattankulathur, Chennai.
  • Requirements: Master degree in Chemistry (Organic / Inorganic chemistry) with a minimum grade of 60%. 
  • Project Durations: 5 years; Initial contract is for 6 months. Later it will be extended, based on his/her performance
  • Other benefits:  Based on his/her performance, the candidate may be entitled to register for Ph.D program of the institute 

Interested candidates please send his/her CV to - Dr. S. Mannathan (Email. ID. For more details, please visit my website:


Dr. S. Mannathan
Research Institute, 13th floor
SRM University,
Ph: No: +919600252532