Research Assistant Professor
Dr. Sitaram Harihar obtained his Ph.D. from Utah State University, USA under the guidance of Prof Daryll DeWald. He was a postdoctoral fellow in the laboratories of Prof. Danny Welch at The University of Kansas Medical Center, USA and Prof. Qi Zeng at the Institute of Molecular and Cell Biology (IMCB), AStar, Singapore. He joined SRM Institute of Science and Technology as a Research Assistant Professor in mid-2016 with joint appointments in the Department of Genetic Engineering and the SRM Research Institute.
The research in my laboratory spans from genes to in vivo studies with expertise in molecular biology, imaging, biochemistry, cell culture and animal models. We aim to address questions broadly centered on understanding the biology of cancer metastasis. Specifically, we study factors contributing to a tumor cell moving from its site of origin to other distant sites in the body. Presently, We are involved in identifying and gaining mechanistic insights into a family of genes regulating metastasis called the metastasis suppressor genes. These genes inhibit metastasis without interrupting primary tumour growth. How metastasis suppressor genes work is largely unknown. Therefore, an understanding of their mechanism of action will help develop a more realistic and less aggressive approach to control/treat cancer instead of relying on therapies that cause drug resistance resulting in more aggressive treatment strategies and concomitant deleterious side effects.
To accomplish this broad objective our focus has centred on studying the mechanism of action of three metastasis suppressor genes KISS1, BRMS1 and ITIH5 in different cancers. The major tumor types studied in my lab are melanoma, breast, pancreatic, but we also have experience in colorectal, prostate and neuroblastoma. We have also ventured into studying ultrastructural and biomechanical properties of cancer cells.
Metastatic cascade and metastasis suppressor’s mechanism of action. Metastasis suppressors arelisted under each step in the metastatic cascade at which they have been experimentally shown to suppress. (Journal of Molecular Medicine, 2014).
Image showing BRMS1 expression specifically altering the cytoskeletal architecture in MDA-MB-435 cells (Cancer Letters, 2010).
Thank you for your interest! For enquires related to B.Tech and M.Tech projects please email me at the address below with a cover letter and CV.
For prospective PhD students, its a big committment both from you and me and this requires that you show enthusiasm and dedication to your career goals. It also requires that I provide you the necessary support (scientific and financial) to pursue your goals.
At present, I am awaiting response to my grant applications. keep looking out for updates!!
Research Assistant Professor
Department of Genetic Engineering and Research Institute
SRM Institute of Science and Technology, Kattankulathur- 603203
Kanchipuram District, Tamil Nadu, INDIA