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Dr. Oindrilla Mukherjee

Dr.rer. nat

Resarch Assistant Professor


I am a Doctorate in Molecular Immunology and Cell Biology from the University of Freiburg, Germany. I worked on dysregulated cellular signalling contributing to allergy and inflammation. I did my postdoctoral studies in Department of Translational Medicine, Lund University, Sweden and at CSIR-IICB, Kolkata. I am interested in understanding the pathogenesis of  bacterial infection prevalent in India.

 


1. Bacterial pathogenesis and  Host-pathogen interaction
My area of research interest includes Infection Biology, with particular focus on bacterial infection and drug development with a goal to establish an infection biology laboratory studying bacterial diseases prevalent in India. The initial research focuses on Helicobacter pylori, a bacterial species that causes gastritis, gastric cancer and gastric MALT lymphoma. Currently antibiotics are the only treatment regime. However, with the large number of outbreaks of antibiotic resistant strains, alternative therapies for this disease are required. The aim of the group would be to study both pathogen and host factors involved in H.pylori mediated gastric cancer and how they can be targeted for alternative therapies.

2. Microbiome
An effort will be made to understand the role of other microorganisms in the gastric microbiota in determining the clinical outcome of gastric cancer. Understanding how the microbiota influences the virulence of H.pylori and delineating the “bad” and the “good” bacteria would lead to crucial information as to why H.pylori causes infection in some humans and not in the others. The aim of the group would be to develop markers and probiotics to regulate the virulence of this bacterium.

B.Tech students:

  • Indratapa Das
  • RoshIni Iyer
  • Swetha Devakumar

  • Sengupta C, Mukherjee O, Chowdhury R. Adherence to intestinal cells promotes biofilm formation and antibiotic resistance in Vibrio cholerae. J Infect Dis. 2016 Sep 16. pii: jiw435.
  • Richter C, Mukherjee O, Ermert D, Singh B, Su-Y.C., Agarwal V, Blom AM, Riesbeck K. Moonlighting of Helicobacter pylori catalase protects against complement-mediated killing by utilising the host molecule vitronectin. Sci Rep. 2016 Apr 18; 6: 24391. doi: 10.1038/srep24391.
  • Bhattacharya S, Mukherjee O, Mukhopadhyay AK, Chowdhury R.  A conserved Helicobacter pylori gene HP0102 is induced upon contact with gastric cells and has multiple roles in pathogenicity. J Infect Dis. 2016 Jul 15; 214(2):196-204. doi: 10.1093/infdis/jiw139.
  • Al-Jubair T, Mukherjee O, Oosterhuis S, Singh B, Su YC, Fleury C, Blom AM, Törnroth-Horsefield S, Riesbeck K. Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells. J Immunol. 2015 Dec 15; 195(12):5688-95. doi: 10.4049/jimmunol.1501197.
  • Su YC, Mukherjee O, Singh B, Hallgren O, Westergren-Thorsson G, Hood D, Riesbeck K. Haemophilus influenzae P4 Interacts With Extracellular Matrix Proteins Promoting Adhesion and Serum Resistance. J Infect Dis. 2015 Jan 15; 213(2):314-23. doi: 10.1093/infdis/jiv374.
  • Singh B, Al-Jubair T, Voraganti C, Andersson T, Mukherjee O, Su YC, Zipfel P, Riesbeck K. Moraxella catarrhalis Binds Plasminogen To Evade Host Innate Immunity. Infect Immun. 2015; 83(9):3458-69. doi: 10.1128/IAI.00310-15.
  • Mukherjee O, Singh B, Bayrak B, Jonsson AB, Mörgelin M, Riesbeck K. A fusion protein derived from Moraxella catarrhalis and Neisseria meningitidis aimed for immune modulation of human B cells. Hum Vaccin Immunother. 2015; 11(9):2223-7. doi: 10.1080/21645515.2015.1034917.
  • Singh B, Su YC, Al-Jubair T, Mukherjee O, Hallström T, Mörgelin M, Blom AM, Riesbeck K. A fine-tuned interaction between trimeric autotransporter haemophilus surface fibrils and vitronectin leads to serum resistance and adherence to respiratory epithelial cells. Infect Immun. 2014; 82(6):2378-89. doi: 10.1128/IAI.01636-13.
  • Mukherjee O, Weingarten L, Padberg I, Pracht C, Sinha R, Hochdörfer T, Kuppig S, Backofen R, Reth M, Huber M. The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: impact on SHIP1/Ig-α interaction. Biochim Biophys Acta. 2012; 1823(2):206-14. doi: 10.1016/j.bbamcr.2011.11.019.
     

Immunotechnology


B.Tech/M.Tech/M.Sc students who are interested in joining the team for short-term projects as well as long term research leading to PhD are welcome to meet me in person or write to me at oindrillamukherjee.s@ktr.srmuniv.ac.in