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Dr. Soumyajit Ghosh

M.Sc., Ph.D

Research Assistant Professor


Dr. Soumyajit Ghosh is working as Research Assistant Professor in Department of Chemistry and SRM Research Institute since October 2016. He did his MSc in chemistry from IIT Delhi in year 2006 and PhD in organic crystal engineering from IISER Kolkata in year 2013 under the supervision of Professor C. Malla Reddy. Title of his PhD thesis was “Mechanical and some other Physico-Chemical Properties of Pharmaceutical Co-crystals: A Crystal Engineering Approach”. After that he pursued his postdoctoral career as DST Young Scientist under Professor Gautam Desiraju, IISc Bangalore. Before joining SRM university he worked as Assistant Manager, Mylan Laboratories Hyderabad. His current research interests are organic crystal engineering, structure-property correlation in molecular crystals, mechanically responsive molecular crystals, pharmaceutical co-crystals and their physico-chemical properties.

Indian Institute of Science Education and Research Kolkata as a PhD student 

  • Structure-property correlation in a series of pharmaceutical co-crystals
  • Co-crystals were designed by crystal engineering approach and characterized by NMR, IR, single crystal XRD, powder XRD, Raman spectroscopy etc.
  • Study of flexible organic crystals. Reported first elastic bendable caffeine co-crystals.
  • Polymorphism was also investigated in few co-crystals and phase transition was explained in the light of theoretical and nanoindentation study.
  •  A series of co-crystals of sulfamethazine and fenamic acids were synthesized in order to achieve better solubility and dissolution properties.

Indian Institute of Science, Bangalore as DST Young Scientist 

  • Designing elastic organic crystals: Highly flexible polyhalogenated N-benzylidineanilines.
  • Design of pharmaceutical co-crystals and study of its physico-chemical properties.
  • Study of structure-property correlation in thermosalient and photosalient organic crystals.

Mylan Laboratories R&D Center, Bollaram, Hyderabad as Assistant Manager 

Understanding the scope and strategy of polymorph screening project, study of literature such as patents, research articles etc.

Determination of solubility, design of various screening methodologies and execution of crystallization experiments on High-Throughput Screening (HTS) platform. Reproducing novel polymorphs manually.

Identifying various crystallization processes for novel forms. 

Papers Presented in Conferences and Schools

  • Poster: Soumyajit Ghosh, AbhisekBasu, Goutam Dev Mukherjee and C. Malla Reddy, “Study of Deformed Organic Crystals by Raman Spectroscopy” at 2nd Inter IISER Chemistry Meet held at IISER Kolkata, 30-31st December, 2009.
  • Poster: Soumyajit Ghosh, AbhisekBasu, Goutam Dev Mukherjee and C. Malla Reddy, “Study of Deformed Organic Crystals by Raman Spectroscopy” at 1st Gordon Research Conference on Crystal Engineering 6-11th June, 2010 NH, USA.
  • Poster: Soumyajit Ghosh, ParthaPratim Bag and C. Malla Reddy, “Co-crystals of Sulfamethazine with some Carboxylic Acids and Amides: Co-Former Assisted Tautomerism in API and Hydrogen Bond Competition Study” at XX International Conference on the Chemistry of the Organic Solid State held at IISc Bangalore 26-30th June 2011.
  • Talk: Soumyajit Ghosh, “Bending Molecular Crystals:Raman and HRTEM study” 1st DCS in-house Symposium held at IISER Kolkata 30-31st December 2010.
  • Poster: Soumyajit Ghosh, ParthaPratim Bag and C. Malla Reddy, “Co-crystals of Sulfamethazine with some Carboxylic Acids and Amides: Co-Former Assisted Tautomerism in API and Hydrogen Bond Competition Study” at Indo-US Bilateral Meeting on The evolving role of solid state Chemistry in Pharmaceutical Science held at Heritage Village Resort & Spa, Manesar (near Gurgaon) 2-4th February 2012.
  • Poster: Soumyajit Ghosh and C. Malla Reddy, “Flexible and Elastically Bendable Caffeine Co-crystals” at Current Trends in Chemistry (Tenth Symposium of CRSI Kolkata Chapter) held at IISER Kolkata 8th August 2012.
  • Poster: Soumyajit Ghosh, Arobendo Mandal, M. S. R. N. Kiran, U. Ramamurty and C. Malla Reddy, “The Role of Weak Interactions in the Phase Transition and Distinct Mechanical Behavior of Two Structurally Similar Caffeine Co-crystal Polymorphs Studied by Nanoindentation” at 2nd Department Day 2013, Department of Chemical Sciences held at IISER Kolkata 11th December, 2013.
  • Attended Mini Symposium on “Designer Molecular Crystals: Mechanical and Functional Properties” at SSCU,IISc Bangalore, 14th November, 2014.
  • Attended International Conference on Structural Chemistry of Molecules and Materials (SCOMM) at Center for Research in Nanoscience & Nanotechnology (CRNN) Kolkata, 30th November-2nd December, 2014.
  • Attended 3rd China-India-singapore (CIS) Conference on Crystal Engineering at SSCU,IISc Bangalore, 8th-10th December 2014.

Awards and Fellowships 

  • Qualified All India Joint admission Test to MSc, IIT JAM 2004 (All India Rank 99).
  • Awarded Senior Research Fellowship by CSIR, Government of India. (July 2011-December 2013).
  • Awarded Junior Research Fellowship by CSIR, Government of India. (July 2009-June 2011).
  • Qualified Graduate Aptitude Test in Engineering (GATE) 2009, 99.03 percentile (All India Rank 63).
  • Best Oral Presentation award at 1st DCS in-house Symposium held at IISER Kolkata 30-31st December 2010.  
  • Recipient of International Travel Grant from Dept. Of Science & Technology (DST), Govt. Of India for attending 1st Gordon Research Conference on Crystal Engineering 6-11th June, 2010 NH, USA.  
  • DST Young Scientist Award 2014.
  • DS Kothari Postdoctoral Fellowship 2014.

 

 

  • Design of mechanically flexible organic crystals
  • Design of thermosalient, photosalient crystals and other mechanically responsive crystals
  • Understanding of mechanical anisotropy and phase change by nanoindentation probe
  • Design of ternary co-crystals
  • Growing single crystals by halogen bonding
  • Development of pharmaceutical co-crystals and understanding various physico-chemical properties.

Some of current research results:

 

Flexible optoelectronic systems which are based on conversion of energy into mechanical motion require fast response times. Materials which show mechanical motion under the influence of different external stimuli such as pressure, heat or light hold promise as self-actuating devices. There are limitations in the response times of polymer based actuating materials and the search for quick response organic materials is gaining momentum. Here, an elastic organic crystal, 2,6-dichlorobenzylidine-4-fluoro-3 nitroaniline (DFNA), which also shows thermosalientbehavior, is studied. The presence of these two distinct properties in the same crystal is unprecedented. The two properties, namely elastic bending and crystal splitting (thermosalient) are attributed to the inherent crystal packing while the mechanisms for bending and thermosalience are quite independent of one another (J. Am. Chem. Soc., 2015, 137, 9912-9921). 

                                                                                                                       

 

Crystalline materials are notoriously brittle, and this is particularly true for organic crystals. Although metal–organic frameworks, which are held together by coordination bonds, can display structural flexibility — such as a 'breathing' behaviour that allows for their lattices expansion and compression — organic crystals rely on weaker non-covalent interactions and are easily broken. Only a handful of flexible organic crystals have been described and in those cases, the irreversible bending arises from the concerted movements of molecular sheets.Herein we report a remarkablyflexible, elastically bendable cocrystal solvate formed fromcaffeine (CAF), 4-chloro-3-nitrobenzoic acid (CNB), and methanol in a 1:1:<1 ratio. The cocrystal solvate1 retains a high internal order through an efficient stressdissipation mechanism, and hence is important in the context of crystal engineering and for the design of flexible organicmaterials (Angew. Chem. Int. Ed., 2012, 51, 10319-10323).

                                                                                          

   

 

Elastic organic crystals may be designed by selecting molecules that are likely to adopt isotropic packing with weak and only moderately polar interactions. The restorative ability of halogen bonds upon application of stress is particularly relevant in this context and is used in this family of Schiff bases (Angew. Chem. Int. Ed., 2015, 54, 2674-2678).

                                                                                      

   

 

 

 

The exceptional mechanical flexibility observed with certain organic crystals defies the common perception of single crystals as brittle objects. Here, we describe the morphostructural consequences of plastic deformation in crystals of hexachlorobenzene that can be bent mechanically at multiple locations to 360° with retention of macroscopic integrity. This extraordinary plasticity proceeds by segregation of the bent section into flexible layers that slide on top of each other, thereby generating domains with slightly different lattice orientations. Microscopic, spectroscopic and diffraction analyses of the bent crystal showed that the preservation of crystal integrity when stress is applied on the (001) face requires sliding of layers by breaking and re-formation of halogen–halogen interactions. Application of stress on the (100) face, in the direction where π···π interactions dominate the packing, leads to immediate crystal disintegration. Within a broader perspective, this study highlights the yet unrecognized extraordinary malleability of molecular crystals withstrongly anisotropic supramolecular interactions (Nature Chemistry, 2015,7(1), 65-72).

                                                    

 


 

Main P.I.

  • Dr. Soumyajit Ghosh

Group Members

  • To be updated soon

 

 

  • Dual Stress and Thermally Driven Mechanical Properties of the Same Organic Crystal: 2,6-Dichlorobenzylidene-4-fluoro-3-nitroaniline, Soumyajit Ghosh, Manish Kumar Mishra, SomnathGanguly and Gautam R. Desiraju (J. Am. Chem. Soc., 2015, 137, 9912-9921)
  • Designing elastic organic crystals: Highly flexible polyhalogenated N-benzylidineanilines Soumyajit Ghosh, Manish Kumar Mishra, Sourabh B. Kadambi, UpadrastaRamamurty and Gautam R. Desiraju Angew. Chem. Int. Ed., 2015, 54, 2674-2678.ISSN:1433-7851, IF: 11.336
  • Spatially resolved analysis of short-range structure perturbations in a plastically bent molecular crystal Manas K. Panda,ǂSoumyajit Ghosh,ǂNobuhiro Yasuda, Taro Moriwaki, Goutam Dev Mukherjee, C. Malla Reddy and PančeNaumov Nature Chemistry, 2015,7(1), 65-72.  ISSN: 1755-4330, Citing References: 20, IF: 25.325. ǂ These authors contributed equally to this work.Highlighted in Nature India, http://www.natureasia.com/en/nindia/article/10.1038/nindia.2015.15
  • Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen ParthaPratim Bag, Soumyajit Ghosh, Hamza Khan, Ramesh Devarapalli and C. Malla ReddyCrystEngComm, 2014, 16, 7393-7396.    ISSN: 1466-8033, IF: 3.858
  • Molecular mechanics of elastic and bendable caffeine co-crystals Chun-Teh Chen, Soumyajit Ghosh, C. Malla Reddy and Markus J. Buehler Phys. Chem. Chem. Phys.,2014, 16, 13165-13171.   ISSN: 1463-9076, IF: 4.198
  • The Role of Weak Interactions in the Phase Transition and Distinct Mechanical Behavior of Two Structurally Similar Caffeine Co-crystal Polymorphs Studied by Nanoindentation Soumyajit Ghosh, Arobendo Mandal, M. S. R. N. Kiran, U. Ramamurty and C. Malla Reddy Cryst. Growth & Des., 2013, 13(10), 4435-4441. ISSN:1528-7483, Citing References: 34, IF: 4.689
  • Elastically Bendable Caffeine Co-crystals: Implications for Flexible Organic Materials Design Soumyajit Ghosh and C. Malla Reddy Angew. Chem. Int. Ed., 2012, 51, 10319-10323. Highlighted in Nature Chemistry, 2012, 4, 866.Highlighted in Nature India, October 2012. Highlighted in Magazine, ChemistryWorld(UK) September issue of 2012Caffeine Crystals with an elastic bent http://www.rsc.org/chemistryworld/2012/09/caffeine-crystals-needles-elastic.ISSN:1433-7851, Citing References: 49, IF: 11.336
  • Polymorphs, Salts, and Cocrystals: What’s in a Name? SrinivasuluAitipamula, Rahul Banerjee, Arvind K. Bansal, Kumar Biradha, Miranda L. Cheney, Angshuman Roy Choudhury, Gautam R. Desiraju, Amol G. Dikundwar, Ritesh Dubey, NagakiranDuggirala, Preetam P. Ghogale, Soumyajit Ghosh, Pramod Kumar Goswami, N. Rajesh Goud, Ram R. K. R. Jetti, Piotr Karpinski, Poonam Kaushik, Dinesh Kumar, Vineet Kumar, Brian Moulton, Arijit Mukherjee, Gargi Mukherjee, Allan S. Myerson, VibhaPuri, ArunachalamRamanan, T. Rajamannar, C. Malla Reddy, Nair Rodriguez-Hornedo, Robin D. Rogers, T. N. Guru Row, Palash Sanphui, Ning Shan, Ganesh Shete, Amit Singh, Changquan C. Sun, Jennifer A. Swift, Ram Thaimattam, Tejender S. Thakur, Rajesh Kumar Thaper, Sajesh P. Thomas, SrinuTothadi, Venu R. Vangala, Narayan Variankaval, PeddyVishweshwar, David R. Weyna, and Michael J. ZaworotkoCryst. Growth & Des., 2012, 12 (5), 2147-2152. ISSN:1528-7483, Citing References: 163, IF: 4.689
  • Co-crystals of caffeine with substituted nitroanilines and nitrobenzoic acids: Structure-mechanical property and thermal studies Soumyajit Ghosh and C. Malla Reddy, CrystEngComm, 2012, 14, 2444-2453. (Featured among Top ten most accessed articles in February 2012) ISSN:1466-8033, Citing References: 9, IF: 3.879
  • Co-Crystals of Sulfamethazine with Some Carboxylic Acids and Amides: Co-Former Assisted Tautomerism in an Active Pharmaceutical Ingredient and Hydrogen Bond Competition Study Soumyajit Ghosh, ParthaPratim Bag and C. Malla Reddy, Cryst. Growth & Des., 2011, 11 (8), 3489–3503.ISSN:1528-7483, Citing References: 56, IF: 4.689
  • Mechanical Properties of Molecular Crystals—Applications to Crystal Engineering C. Malla Reddy, G. Rama Krishna, and Soumyajit Ghosh CrystEngComm,2010, 12, 2296-2314. Highlight From themed issue New Talent).ISSN:1466-8033, Citing References: 70, IF: 3.858 
  • Cross Linking of Gold Nanoparticles with Hexa-peri-hexabenzocoronene Derivatives SivamuruganVajiravelu, Soumyajit Ghosh, and Suresh ValiyaveettilJ. Nanosci. Nanotechnol., 2009, 9, 6587. ISSN:1533-4880, IF: 1.149

Patents Published:

  • WO/2016/125190 ―Novel Crystalline Forms Of Vortioxetine, Premixes,And Processes For The Preparation Thereof
  • WO/2017/046815 ―Polymorphs of Ixazomib Citrate and Processes For the Preparation Thereof
  • WO/2017/056109 ―Novel Forms of Lumacaftor and Processes For the Preparation Thereof
  • WO/2017/077551 ―An Amorphous Nintedanib Esylate and Solid Dispersion Thereof

  • BSc Chemistry: Organic Reagents and Reaction Mechanisms
  • BTech: Environmental Science

 

 

Postdoctoral Positions
Interested candidates can directly contact Dr. Soumyajit Ghosh

PhD

Applications are invited for the position of Junior Research Fellow for a DST-SERB project, Department of Chemistry, Research Institute, SRM University, Chennai-603203.

ECRA (Early Career Research Award) approved for funding (2017) with a grant of Rs. 44 lakhs. Project Title: Design of Mechanically Dual Responsive Molecular Crystals: A Crystal Engineering Approach

Essential Qualifications: M.Sc. in Chemistry securing minimum first class marks or equivalent CGPA. NET/GATE qualified candidates or candidates having synthetic organic chemistry background will be given preference.

Candidate will work in crystal engineering field and register for PhD programme at SRM university.

Number of Positions: One

Duration of the project: Three years

Amount of fellowship:

NET/GATE qualified candidate: Rs. 25,000/-p.m. for initial two years and Rs. 28,000/-p.m. the third year onwards.

Non-NET/GATE candidates: Rs. 16,000/-p.m. for initial two years and Rs. 18,000/-p.m. from the third year onwards. The JRF will be also entitled for getting 10% HRA (HRA admissible if the stay is outside the campus).

Interested candidates please send his/her CV to - Dr. Soumyajit Ghosh

(Email:ID: soumyajitghosh.s@ktr.srmuniv.ac.in)

Dr. Soumyajit Ghosh
Research Assistant Professor
Office 709A, 7th Floor, University Main Building
Department of Chemistry and Research Institute, Kattankulathur Campus, SRM University
Chennai – 603203
Mobile No. 9908236087
Email: soumyajitghosh.s@ktr.srmuniv.ac.in