ramkumar.jpg

Dr. Ramkumar

Ph.D

Associate Professor


Dr. Ramkumar is working as an Associate Professor in Life Sciences division at SRM Research Institute and associated with the Department of Biotechnology at SRM University, since December 2011. He received his doctoral degree from Bharathidasan University, Tiruchirapallai, India, where he trained in experimental diabetes particularly pancreatic β-cell apoptosis. He expanded his training into the cellular pathophysiology of diabetes during his Post-doctoral Fellowship at the Chonbuk National University Medical School, Republic of Korea; and developing molecular imaging methods to study the protective molecular pathways Improving pancreatic β-cell dysfunction in diabetes during his research at the Cellular Pathway Imaging Laboratory at the Stanford University School of Medicine, USA.

Academic Profile

  • Ph.D. Biotechnology (2008) - Bharathidasan University, Tiruchirappalli, India
  • M.Phil. Biochemistry (2001)- Annamalai University, Annamalainagar, India
  • M.Sc. Biochemistry (1999)- Bharathidasan University, Tiruchirappalli, India 
  • B.Sc. Biochemistry (1997)-Madurai Kamaraj University, Madurai, India 

Employment details

  • Dec 2011 to till date -Research Assistant Professor, SRM Research Institute, SRM University, Kattankulathur, india
  • Jan 2012 to Jul 2012-Visiting Assistant professor, Stanford University School of Medicine, Stanford University, California, USA
  • Jul 2010 to Dec 2011-Assistant Professor, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, india
  • Dec 2008 to Jun 2010-Post-Doctoral Fellow, Chonbuk National University Medical School, Jeonju, Republic of Korea
  • Apr 2006 to Nov 2008-CSIR-Senior Research Fellow - Bharathidasan University, Tiruchirappalli, India
  • Aug 2004 to Sep 2005-DRDO- Junior Research Fellow- Bharathiar University, Coimbatore, India

Awards and Honors :

  • DBT-International Travel Grant to attend American Diabetes Association Conference' 2016
  • DBT-International Travel Grant to attend American Diabetes Association Conference' 2013
  • Best presentation Award at World congress on Diabetes India, 2013
  • Recipient of ‘Faculty Abroad Program’ fellowship from SRM University 2012
  • Brain Korea Fellowship 2009-2010
  • Best presentation Award at International Conference on Biomarkers, 2008
  • Young Scientist award from Cell Stress Society International, 2007
  • DST-International Travel Grant to attend Cell Stress Society International, Budapest, 2007
  • Senior Research Fellowship (SRF) from Council of Scientific and Industrial Research (CSIR), Govt. of INDIA, 2005
  • Junior Research Fellowship (JRF) from Defence Research and Development Organization (DRDO) , Govt. of INDIA, 2004
  • Kalaikavalar award for overall Performance during Post-graduate studies, 1999
  • College Management medal for academic excellence (first rank) during Post-graduate studies, 1999
  • St. Mary’s Tope Centenary medal for academic performance during Post-graduate studies. 1998
  • University Gold medal for academic excellence during Under -graduate studies, 1997

Research Grants

Funding agency

Title

Role

Amount

(INR. In Lakhs)

Duration

Status

Ongoing/completed

Department of Science & Technology

(DST-SERB)

A cell-based system for high throughput screening of Nrf2 activators and its role in protecting pancreatic β-cell apoptosis

PI

24.12

Aug 2013-                           Completed

July 2016                         

Department of Biotechnology

(DBT)

Nuclear factor erythroid 2-related factor 2 (Nrf2) activators on the survival of pancreatic islet grafts in type 1 diabetic mice

PI

 42.95

May 2014-

Nov 2017

                Ongoing

Indian Council of  Medical Research (ICMR)

Study on the effect of Gymnema montanum on endothelial dysfunction in experimental diabetes

PI

28.80

Jun 2015-                   Ongoing

May 2018

Department of Biotechnology (DBT)

SRM-DBT Platform for Research and Skill Development in Advanced Life Science Technologies

PI

1576.00

Oct 2015-

Sep 2020

             Ongoing

Department of Biotechnology (DBT: Indo-US)

A rapid non-invasive urinary test for the detection of  Obstructive Uropathy

Co-PI

37.19

Nov 2015-               Ongoing

Feb 2018

Science and Engineering Research Board (SERB)

Therapeutic potential of Nrf2 activators on Enoplasmic reticulum-induced endothelial dysfunction in diabetes

          PI

50.54

Oct 2017-                           Ongoing

Sep 2010

Professional Memberships

  • American Diabetes Association (ADA)
  • Society for Free Radical Biology Medicine (SFRBM)
  • Environmental Mutagen Society of India (EMSI)
  • Society of Biological Chemist (SBC)
  • Indian Science Congress Association (ISCA)
  • World Community Service Centre, India Chapter (WCSC)

Dr. K M Ramkumar’s research group is working on experimental diabetes research using high-end molecular and cellular biology tools, non-invasive and microscopical imaging. The pathogenic processes involving in the development of diabetes range from autoimmune destruction of pancreatic β-cells with consequent insulin deficiency to abnormalities that result in resistance to insulin action. The major contributing factor for excessive β-cell death includes cytokine stress, ER stress and oxidative stress-mediated mitochondrial damage, which creates an imbalance in redox homeostasis. Yet, β-cells have evolved adaptive mechanisms to endure a wide range of stress conditions to safeguard its potential functions. We extended our research on the detailed steps of various cell signaling pathways in response to modulators for diabetes management. We are developing molecular imaging techniques for screening signaling modulators and also studying the molecular mechanism of its impact β-cell dysfunction in diabetes. We do work the effect of cell signaling modulators on the cross-talk between pancreatic endothelial cells and pancreatic islet cells. We also work on mass spectrometry based label-free quantitative proteomics analysis to identify and quantify differentially regulated proteins in microalbuminuric and normoalbuminuric type 2 diabetic patients and investigate the associations that would reflect the progress of Diabetic Nephropathy.

Research Area

  • Protective Molecular Pathways Improving pancreatic β-cell dysfunction
  • Developing high-throughput cell-based assays to screen cell signaling modulators
  • Cross talk between endothelial cells and pancreatic Islets
  • Differential proteomic analysis of pathway biomarkers in diabetes
  • Role of Nrf2 activators on Islet transplantation

Research Facilities Available

  1.  Animal Cell culture facility
  2. RNA work station (Bioanalyzer, PCR, qRT-PCR)
  3. Protein Work Station (Western Blotting, ELISA)
  4. Imaging and documentation facility (Microscopy, Chemi-documentation system, Live Small animal imaging, Luminometer)
  5. Immunohistochemistry and Immunocytochemistry facility

Group Leader

  • Dr. K.M. Ramkumar

Ph.D students - 1

  1. Sireesh Dornadula- Mechanism of Nrf2 activation by pterostilbene in pancreatic β-cells and its role on the survival of pancreatic islet grafts in type 1 diabetic mice

Postdoctoral fellows - 2

  1. Dhamodharan Umapathy-MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy 
  2. R. Vijayakumar-Urinary proteome analysis and the management of ureteropelvic junction obstruction

Ph. D completed - 5

  1. Bhakkiyalakshmi Elango - 2015-Studies on the Nrf2 Activation Potential of Pterostilbene and its Therapeutic Role in Diabetes
  2. Rajshree Raghunath - 2015-Population study and evaluation of Y-STR markers in Irula tribe of Tamil Nadu
  3. Vanitha Pachaimuthu - 2016-Study on the protective effect of morin against high glucose-induced β-cell apoptosis and streptozotocin-induced diabetes mellitus
  4. Uma Chidambaram - 2016 -Evaluation of antihyperglycemic and antiapoptotic effects of Codariocalyx motorius root extract against streptozotocin-induced diabetes
  5. Suganya Natarajan- ​2017 - Ameliorative effect of Quercetin against Endoplasmic Reticulum stress-induced Endothelial Dysfunction in diabetes
  • Total number of publications – 58
  • h-index – 21
  • i10 index – 35

Publications

  • Dhamodharan U, Sireesh D, Arvind Rajagopalan, Narayana murthy, Vairamani M, Rajesh Kesavan, Ramkumar KM*. Potential of circulatory Procalcitonin as a biomarker reflecting Inflammation among South Indian Diabetic Foot Ulcer. Journal of vascular Surgery, 2017 (In press) (Impact Factor: 3.454)
  • Dhamodharan U, Ezhilarasi K, Vairamani M, Viswanathan V, Ramkumar KM*. Increased levels of circulating (TNF-α) is associated with (-308G/A) promoter polymorphism of TNF-α gene in Diabetic Nephropathy. International Journal of Biological Macromolecules , 2017 (In press) (Impact Factor: 3.6)
  • Sireesh D, Ganesh MR, Dhamodharan U, Sakthivadivel M, Sivasubramanian S, Gunasekaran P, Ramkumar KM*. Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade. Journal of Nutritional Biochemistry, 2017; 44: 11-21. (Impact Factor: 4.668)
  • Sarvani C, Sireesh D, Ramkumar KM*. Unraveling the role of ER stress inhibitors in the context of metabolic diseases. Pharmacological Research, 2017;119:412-421. (Impact Factor: 4.816)
  • Dhamodharan U, Ezhilarasi K, Ponjayanthi B, Sireesh D, Ramkumar KM*, Viswanathan V*. Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population. Bioscience Reports, 2017 Mar 27;37(2). (Impact Factor: 2.446)
  • Vanitha P, Senthilkumar S, Dornadula S, Anandhakumar S, Rajaguru P, Ramkumar KM*. Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells. European Journal of Pharmacology, 2017;801:9-18 (Impact Factor: 2.53)
  • Anandhakumar S*, Krishnamoorthy G, Ramkumar KM, Raichur AM. Preparation of collagen peptide functionalized chitosan nanoparticles by ionic gelation method: An effective carrier system for encapsulation and release of doxorubicin for cancer drug delivery. Materials Science and Engineering: C, 2017;70: 378-385  (Impact Factor: 3.42)
  • Bhakkiyalakshmi E, Sireesh D, Paulmurugan R, Ramkumar KM*. Pterostilbene ameliorates streptozotocin-induced diabetes through enhancing antioxidant signaling pathways mediated by Nrf2. ACS-Chemical Research in Toxicology, 2016;29(1):47-57 (Impact Factor: 3.52)
  • Suganya N, Bhakkiyalakshmi E, SaradaDVL, Ramkumar KM*. Reversibility of Endothelial Dysfunction in Diabetes: Role of Polyphenols. British Journal of Nutrition 2016; 116(2):223-246 (Impact Factor: 3.31)
  • Bhakkiyalakshmi E, Dineshkumar K, Karthik S, Sireesh D, Waheetha Hooper, Paulmurugan R, Ramkumar KM*. Pterostilbene-mediated Nrf2 activation: Mechanistic Insights on Nrf2:Keap1 Interface. Bioorganic & Medicinal Chemistry, 2016; 24(16):3378–3386 (Impact Factor: 2.92)
  • Bhakkiyalakshmi E, Sireesh D, Sakthivadivel M, Sivasubramanian S, Gunasekaran P, Ramkumar KM*. Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes. European Journal of Pharmacology 2016;777: 9-16  (Impact Factor: 2.73)
  • Anandhakumar S, Krishnamoorthy G, Ramkumar KM, Raichur A.M. Preparation of collagen peptide functionalized chitosan nanoparticles by ionic gelation method: An effective carrier system for encapsulation and release of doxorubicin for cancer drug delivery. Materials Science & Engineering C 2017; 70(1): 378–385 (Impact Factor: 3.4)
  • Bhakkiyalakshmi E, Suganya N, Sireesh D, Krishnamurthi K,  Devi S, Rajaguru P, Paulmurugan R, Ramkumar KM*. Carvacrol induces mitochondria-mediated apoptosis in HL-60 promyelocytic and Jurkat T lymphoma cells. European Journal of Pharmacology 2016;772:92-98 (Impact Factor: 2.73)
  • Rajshree R,  Kamalakshi K,  Lakshmi B, Ramkumar KM. Genetic portrait of Tamil non-tribal and Irula tribal population using Y chromosome STR markers. International Journal of Legal Medicine, 2016; 130: 367–369 (Impact Factor: 2.86)  
  • Sireesh D, Bhakkiyalakshmi E, Ponjayanthi B, Rajaguru P, Ramkumar KM*. Pathophysiological insights of methylglyoxal induced Type-2 Diabetes. ACS-Chemical Research in Toxicology, 2015; 28(9):1666-1674. (Impact Factor: 3.52)
  • Bhakkiyalakshmi E, Sireesh D, Rajaguru P, Paulmurugan R, Ramkumar KM*. The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes. Pharmacological Research, 2015; 91: 104-114.  (Impact Factor: 4.82)
  • Sireesh D, Bhakkiyalakshmi E, Ramkumar KM, Kumar SR, Jennifer PA, Rajaguru P, Paulmurugan R. Targeting SUMOylation Cascade for Diabetes Management. Current Drug Targets, 2014; 15(12): 1094-1106 (Impact Factor: 3.03)
  • Uma C, Suganya N, Vanitha P, Bhakkiyalakshmi E, Suriyanarayanan S, Maria John KM, Sivasubramanian S, Gunasekaran P, Ramkumar KM*. Antihyperglycemic effect of Codariocalyxmotorius modulated carbohydrate metabolic enzyme activities in streptozotocin-induced diabetic rats. Journal of Functional Foods, 2014;11: 517-527 (Impact Factor: 3.97)
  • Suganya N, Bhakkiyalakshmi E, Subin TS, Krishnamurthi K,  Devi S, Lau K, Sekar TV, Paulmurugan R, Ramkumar KM*. Proteomic identification of pterostilbene mediated anticancer activities in HepG2 cells. ACS-Chemical Research in Toxicology, 2014; 27(7): 1243-1252(Impact Factor: 3.52)
  • Bhakkiyalakshmi E, Shalini D, Thillai VS, Rajaguru P, Paulmurugan R, Ramkumar KM*. Therapeutic potential of pterostilbene against pancreatic β-cell apoptosis through Nrf2 mechanism. British Journal of Pharmacology, 2014; 171(7): 1747-1757. (Impact Factor: 5.26)  
  • Vanitha P, Uma C, Suganya N, Bhakkiyalakshmi E, Suriyanarayanan S, Gunasekaran P, Sivasubramanian S, Ramkumar KM*. Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environmental Toxicology and Pharmacology, 2014; 37(1): 326-335. (Impact Factor: 2.18)
  • Suganya N, Bhakkiyalakshmi E, Suriyanarayanan S, Paulmurugan R, Ramkumar KM*. Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells. Cell proliferation 2014;47(3):231-240.(Impact Factor: 3.08)
  • Ramkumar KM*, Vijayakumar RS, Vanitha P, Suganya N, Manjula C, Rajaguru P, Sivasubramanian S, Gunasekaran P. Protective effect of Gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats. Human and Experimental Toxicology, 2014; 33(6): 638-649. (Impact Factor: 1.6)
  • Sekar TV, Ramkumar KM, Kira F and Paulmurugan R. Therapeutic Evaluation of microRNAs by Molecular Imaging. Theranostics 2013; 3(12): 964-985. (Impact Factor: 8.85)  
  • Ramkumar KM, Sekar TV, Kira F, Bhakkiyalakshmi E and Paulmurugan RReporter Protein Complementation Imaging Assay to Screen and Study Nrf2 Activators in Cells and Living Animals. ACS- Analytical chemistry, 2013; 85(15): 7542-7549. (Impact Factor: 5.89)
  • Ramkumar KM*, Manjula C, Bhakkiyalakshmi E, Krishnamurthi K, Devi SS, Rajaguru P. In vitro cytotoxicity of Gymnema montanum in human leukemia HL-60 cells: Induction of apoptotic cell death by mitochondrial membrane potential collapse. Cell proliferation 2013; 46(3): 263-271. (Impact Factor: 3.11)
  • Ramkumar KM, Sekar TV, Bhakkiyalakshmi E, Kira F, Rajaguru P, Berger F and Paulmurugan R. The impact of oxidative stress on islet transplantation and monitoring the graft survival by non-invasive imaging. Current Medicinal chemistry 2013; 20(9): 1127-1146 (Impact Factor: 3.45).
  • Chidambaram U, Pachamuthu V, Natarajan S, Elango B, Suriyanarayanan, Ramkumar KM*. In vitro evaluation of free radical scavenging activity of Codariocalyxmotorius root extract. Asian Pacific Journal of Tropical Medicine 2013; 6(3): 188-94.(Impact Factor: 0.84)  
  • Ramkumar KM*, Manjula C, Gnanakumar G, Kanjwal MA, Sekar TV, Paulmurugan R, Rajaguru P. Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO(2) nanofibers in HeLa cells. European Journal of Pharmaceutics and Biopharmaceutics 2012; 81(2): 324-333. (Impact Factor: 3.975)
  • Ramkumar KM*, Vanitha P, Uma C, Suganya N, Bhakkiyalakshmi E, Sujatha J. Antidiabetic activity of alcoholic stem extract of Gymnema montanum in streptozotocin-induced diabetic rats. Food and Chemical Toxicology 2011; 49(12): 3390-3394. (Impact Factor: 3.58)
  • Kim DH, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American Journal of Physiology and Renal Physiology. 2011;301(2):F427-35. (Impact factor: 3.39)  
  • Kang KP, Park SK, Kim DH, Sung MJ, Jung YJ, Lee AS, Lee JE, Ramkumar KM, Lee S, Park MH, Roh SG, Kim W. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrology Dialysis and Transplantation. 2011;26(3):814-22. (Impact factor: 4.085)  
  • Ramkumar KM, Sankar L, Manjula C, Krishnamurthi K, Devi SS, Chakrabarti T, Kalaiselvi K, Palanivel M, Rajaguru P. Antigenotoxic potential of Gymnema montanum leaves on DNA damage in human peripheral blood lymphocytes and HL-60 cell line. Environmental Molecular Mutagenesis. 2010;51(4):285-93. (Impact Factor: 3.326)
  • Ramkumar KM, Thayumanavan B, Palvannan T, Rajaguru P. Inhibitory effect of Gymnema montanum leaves on α-glucosidase activity and α-amylase activity and their relationship with polyphenolic content. Medicinal Chemistry Research. 2010; 19(8):  948-961.(Impact Factor: 1.436)  
  • Angayarkanni J, Ramkumar KM, Priyadharshini U, Ravendran P. Antioxidant potential of Amorphophallus paeoniifolius in relation to their phenolic content. Pharmaceutical Biology. 2010; 48(6):659-65. (Impact factor: 1.546)
  • Ramkumar KM, Lee AS, Krishnamurthi K, Devi SS, Chakrabarti T, Kang KP, Lee S, Kim W, Park SK, Lee NH, Rajaguru P. Gymnema montanum H. protects against alloxan-induced oxidative stress and apoptosis in pancreatic beta-cells. Cell Physiology and Biochemistry. 2009;24(5-6):429-40. (Impact factor: 4.65)
  • Ramkumar KM, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats. Food and Chemical Toxicology. 2009;47(10):2516-21. (Impact Factor: 3.584)
  • Latha M, Pari L, Ramkumar KM, Rajaguru P, Suresh T, Dhanabal T, Sitasawad S, Bhonde R. Antidiabetic effects of scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes. Natural Product Research. 2009;23(16):1528-40. (Impact Factor: 1.05)
  • Ramkumar KM, Manjula C, Sankar L, Suriyanarayanan S, Rajaguru P. Potential in vitro antioxidant and protective effects of Gymnemamontanum H. on alloxan-induced oxidative damage in pancreatic beta-cells, HIT-T15. Food and Chemical Toxicology. 2009; 47(9):2246-56. (Impact Factor: 3.584)
  • Ramanan R,  Krishnamurthi K, Vinayagamoorthi N, Ramkumar KM, Saravana Devi S and Chakrabarti T. Purification and Characterization of a Novel Plant-type Carbonic Anhydrase from Bacillus subtilis. Biotechnology and Bioprocess Engineering. 2009; 14: 32-37 (Impact Factor: 1.21)
  • Ramkumar KM, Vijayakumar RS, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. Antihyperlipidaemic effect of Gymnemamontanum: a study on lipid profile and fatty acid composition in experimental diabetes. Basic Clinical Pharmacology and Toxicology. 2008;103(6):538-45. (Impact Factor: 3.097)
  • Ramkumar KM, Rajaguru P, Latha M, Ananthan R. Effect of Gymnema montanum leaves on red blood cell resistance to oxidative stress in experimental diabetes. Cell Biology and Toxicology. 2008;24(3):233-41. (Impact Factor: 2.84)
  • Vijaya Padma V, Arul Diana Christie S, Ramkuma KM. Induction of apoptosis by ginger in HEp-2 cell line is mediated by reactive oxygen species. Basic Clinical Pharmacology and Toxicology. 2007; 100(5): 302-7. (Impact Factor: 3.097)
  • Ramkumar KM, Rajaguru P, Muniappan L and Ananthan R. Ethanol extract of Gymnem amontanum leaves reduces glycoprotein components in experimental diabetes. Nutritional Research. 2007; 27 (2): 97–103 (Impact Factor: 2.523)
  • Ramkumar KM, Rajaguru P and nanthan R. Antimicrobial Properties and Phytochemical Constituents of an Antidiabetic Plant Gymnema montanum. Advances in Biological Research. 2007; 1(1-2): 67-71.
  • Suriyanarayanan S, Ramkumar KM, Latha M and Rajesh Kannan V.Antimicrobial and free radical scavenging activity of Cassia auriculataL.flowers.International Journal of Natural and  Applied Science. 2007; 3(1):39-42.
  • Vijaya Padma V, Shyamala Devi CS, Ramkumar KM. Effect of fish oil pretreatment on isoproterenol-induced changes in myocardial membrane phospholipids. Nutrition. 2006;22(11-12):1171-6. (Impact Factor: 2.839)
  • Latha M, Ramkumar KM, Pari L, Damodaran PN, Rajeshkannan V, Suresh T. Phytochemical and antimicrobial study of an antidiabetic plant: Scoparia dulcis L. Journal of Medicinal Food. 2006; 9(3):391-4. (Impact Factor: 1.844)
  • Ashokkumar N, Pari L, Ramkumar KM. N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats. Basic Clinical Pharmacology and Toxicology. 2006;99(3):246-50. (Impact Factor: 3.097)
  • Ramkumar KM. Health promotion by dietary restriction--a focus. Journal of Basic Clinical Physiology and Pharmacology. 2006;17(2):101-14. (Impact Factor: 0.75)
  • Padma VV, Devi CS, Ramkumar KM. Modulatory effect of fish oil on the myocardial antioxidant defense system in isoproterenol-induced myocardial infarction. Journal of Basic Clinical Physiology and Pharmacology. 2006;17(1):1-15.(Impact Factor: 0.75)
  • Ramkumar KM, Anuradha CV. Short-term dietary restriction modulates liver lipid peroxidation in carbon tetrachloride-intoxicated rats. Journal of Basic Clinical Physiology and Pharmacology. 2005;16(4):245-56.(Impact Factor: 0.75)
  • Ramkumar KM, Latha M, Ashokkumar N, Pari L, Ananthan R. Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. Journal of Basic Clinical Physiology and Pharmacology 2005;16(1):17-35.(Impact Factor: 0.75)
  • Ramkumar KM, Latha M, Venkateswaran S, Pari L, Ananthan R, Bai VN. Modulatory effect of Gymnema montanum leaf extract on brain antioxidant status and lipid peroxidation in diabetic rats. Journal of Medicinal Food. 20047(3):366-71.  (Impact Factor: 1.844)
  • Ananthan R, Latha M, Ramkumar KM, Pari L, Baskar C, NarmathaBai V. Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats. Experimental Diabetes Research. 2003;4(3):183-9. (Impact Factor: 1.2)
  • Ananthan R, Latha M, Ramkumar KM, Pari L, Baskar C, NarmathaBai V. Modulatory effects of Gymnema montanum leaf extract on alloxan-induced oxidative stress in Wistar rats. Nutrition. 2004 ;20(3):280-5. (Impact Factor: 2.839)
  • Ananthan R, Baskar C, NarmathaBai V, Pari L, Latha M, Ramkumar KM. Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes. Pharmacological Research. 2003; 48(6):551-6. (Impact factor: 4.816)
  • Ananthan R, Latha M, Pari L, Ramkumar KM, Baskar CG, Bai VN. Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats. Journal of Medicinal Food. 2003;6(1):43-9. (Impact Factor: 1.844)
  • Ramkumar KM, Rajesh R, Anuradha CV. Food restriction attenuates blood lipid peroxidation in carbon tetrachloride-intoxicated rats. Nutrition. 2003 Apr;19(4):358-62. (Impact Factor: 2.839)

Abstract Publications in reputed journals

  • Ramkumar KM*, Bhakkiyalakshmi E, Sireesh D, Paulmurugan R. Therapeutic Potential of Nrf2 Activator Pterostilbene in Streptozotocin-Induced Diabetic Nephropathy. Diabetes, 2016; 65(1), A131. (Impact factor : 8.79)
  • Dhamodharan U, Ponjayanthi B, Sireesh D, Ramkumar KM*. Nrf-2 Gene Polymorphism is Associated with an Increased Risk of Diabetic Foot Ulcer among South Indian Population. Diabetes, 2016; 65(1), A425. (Impact factor : 8.79)
  • Ramkumar KM, Thillai VS, Kira F, Bhakkiyalakshmi E, Paulmurugan R. Reporter Protein Complementation System Identifies Pterostilbene as Nrf2 Activator and Protects Pancreatic β-Cells Against Apoptosis. Diabetes, 2013; 62(1), LB51. (Impact factor : 8.79)
  • Ramkumar KM, Vinayagamoorthy N, Kannan K, Tapan C, Kang KP, Lee S, Kim W, Park TS, Takayoshi S, Palanisamy R, Park SK. Proteomic Study of the Antidiabetic Effect of Gymnema montanum in Alloxan-Induced Diabetic Rats. Diabetes, 2010; 59 (1): A569. (Impact factor : 8.79)
  • Ramkumar KM, Rajaguru P, Kim DH, Jung YJ, Lee AS, Lee JE, Kang KP, Lee S, Kim W,  Park SK. Effect of polyphenolic extract of Gymnema montanum on renal oxidative stress pathways in experimental diabetic rats. Journal of the American Society of Nephrology, 2009; 20: PUB120. (Impact factor : 9.34)

Chapters published in Books

  • Bhakkiyalakshmi E, Sireesh D, Ramkumar KM*. Redox sensitive transcription via Nrf2-Keap1 in suppression of Inflammation. In: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support: Immunity and Inflammation in Health and Disease, Editors: Chatterjee S., Bagchi D. and Billie Jean Fernandez. Elsevier Press, USA; 2017 (In press)
  • Paridhy VS, Sireesh D,Dhamodharan U,  Ponjayanthi B, Srikumari Srisailapathy CR, Ramkumar KM*. Keap1. In: Encyclopedia of Signaling Molecules, 2nd Edition, Editors: Sangdun Choi, Springer Press, NY, USA; 2017 (In press)

  • Amala Reddy, Sujatha S and Ramkumar KM*. New insights in the management of metabolic disorder in pharmacology: A review with reference to Adathoda vasica for Diabetes mellitus. In Metabolic Disorders, Vol 2; Editors: Govil JN, Singh VK and Siddiqui NT, Studium Press, Texas; 2017 (In press)
  • Sireesh D, Bhakkiyalakshmi E, Ponjayanthi B, Ramkumar KM*. The crucial role of Nrf2-ARE pathway in defense against hepatotoxicity. In: Hepatotoxicity: Symptoms, Management and Health Implications, Editors: Rajagopal S. and Murugan S. Nova Science Publishers NY, USA ; 2015: 293-317.
  • Ramkumar KM, Rajaguru P, Latha M and Ananthan R. Amelioration of metabolic complications   associated with diabetes by Gymnema montanum in alloxan induced rats. In: Recent progress in medicinal plants, Vol.18; Govil JN, Singh VK, Siddiqui NT, editors. Texas: Studium Press, LLC; 2007: 319-338.

 


  • Protein Engineering (BT0304) – for B.Tech. Biotechnology students IIIrd Semester
  • Enzyme Technology (BT0201) - for B.Tech. Genetic Engineering students- IInd Semester
  • Cancer Biology (BT2101) – for M.Tech Biotechnology, IInd semester
  • Developmental Biology (15BT207E) - for B.Tech. Biotechnology students IIIrd Semester

 

 


B.Tech/M.Tech students who are willing to join in my research group for short-term projects are welcome

Postdoctoral Positions:

  • Will be updated soon

Ph.D

  • Two vacancies are available

For further details, please visit

http://www.srmuniv.ac.in/careers/faculty/jrf-serb-project-biotech-2017

Project Assistants

  • Will be updated soon

Contact:
Dr. K.M. Ramkumar
Research Assistant Professor
SRM Research Institute
SRM University, Kattankulathur-603203,
Tamilnadu, India
Email: ramkumar.km@res.srmuniv.ac.in