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Dr. S. Anandhakumar

Ph.D

Research Assistant Professor


Dr. S. Anandhakumar joined as an Assistant Professor in Research Institute and associated with the Department of Physics and Nanotechnology at SRM University, since April 2012. He has got his Ph.D from Department of Materials Engineering, Indian Institute of Science (IISc), Bangalore., and intensively worked on stimuli-responsive polyelectrolyte capsules for encapsulation and release of macromolecules in response to environmental (pH, temperature, and ionic strength) and external (laser light and ultra sound) stimuli. He has expanded his research focus on designing functional polymers to synthesize LCST polymers for specific biomedical applications via cationic ring opening polymerization (CROP) by visiting University of Ghent, Belgium., as Visiting Assistant Professor. He has also worked as Visiting Assistant Professor at University of Wisconsin-Madison, USA, and involved in developing various methodologies to modify the surfaces of screen printed and glass carbon electrodes for sensing of biomolecules and heavy metal ions.

Education:

  • Ph.D. Materials Engineering (CGPA 7.0/8.0), Indian Institute of Science (IISc), Bangalore, India (2006 - 2011)
  • M.Tech. Ceramic Technology (CGPA 9.1/10), Anna University, Chennai, India (2004 - 2006)
  • B.Tech. Chemical Engineering (72%), Madras University, Chennai, India (2000 - 2003)
  • D.CH. Chemical Engineering (73%), Directorate of Technical Education, Tamil Nadu, India (1997 - 2000)

Awards/Scholarship/Official Appreciation

  • Visiting Assistant professor, University of Wisconsin-Madison, USA (February 2017-May 2017)
  • Visiting Assistant professor, Ghent University, Belgium (February 2014 - April 2014)
  • Prof. R M Mallya (Best Ph.D Thesis) Award, Indian Institute of Science, India
  • One among four candidates called for presentation of young scientist award for the academic year 2011-2012 in Engineering Sciences by Indian Science Congress association (ISCA), India.
  • Research Associate, Indian Institute of Science, India (June 2011 - March 2012)
  • Travel grant to attend the conference in Singapore, Indian Institute of Science, Bangalore
  • Ministry of Human Resource Development (MHRD) Research Fellow, Indian Institute of Science (August 2006 - July 2011)
  • MHRD Graduate Student fellowship (July 2004 - July 2006)
  • University rank holder (3rd ranking) in post graduation, Anna University, India
  • GATE (Graduate Aptitude Test in Engineering) Qualified in Chemical Engineering, MHRD, Govt. of India. (2004)

Projects

  • Project Title: Novel Stimuli-responsive Poly(2-oxazoline)s/Tannic Acid Multilayer Thin Films and Capsules for Drug Delivery Applications, PI: Anandhakumar Sundaramurthy – Feb 2016 to Feb 2019. On-going.
  • Project Title: Experimental and Numerical Investigation of Estimation of Drug Release from Hollow Microstructures in a Microchannel Fluid Flow for Sustained Drug Delivery Applications, Co-PI: Anandhakumar Sundaramurthy - Submitted.

 


Research Interests

  • Nano-carriers and Thin Film Based Drug Delivery Systems
  • Stimuli Responsive and Remotely Triggerable Drug Delivery Systems
  • Bioresponsive and Biomimetic Coatings
  • Bio-imaging and Sensing
  • Polymer Synthesis by CROP Polymerization
  • Polymeric Scaffolds

His research focuses at the interface between materials science and biology to develop new approaches that helps solving complex problems in design of multi-functional, responsive materials for drug delivery, bioimaging and regenerative medicine. The goal is to use surface and colloid chemistry principles in developing novel bio-inspired synthetic routes that would lead to advanced biomaterials.

Drug Delivery. Research focuses on polyelectrolyte capsules and thin films for controlled and remotely activated drug delivery

  • Preparation of stimuli-responsive polyelectrolyte capsules and thin films
  • Investigation of their permeability and stability
  • Study of various loading and release mechanisms to increase their encapsulation efficiency and release time
  • Remotely activated drug delivery of proteins and other pharmaceutical drugs using laser or ultrasound as triggers

Polymer Synthesis. Research focuses on poly(2-alkyl-2-oxazolines) (PAOx) synthesis for biomedical applications

  • PAOx synthesis by CROP polymerization
  • Layer-by-Layer (LbL) assembly of tannic acid (TA)/PAOx thin films and free standing carriers for biomedical applications

Sensing of Biomolecules. Research focuses on modification of glassy carbon and screen printed electrodes using thin films and nanoparticles for sensing of biomolecules

  • Modification of electrodes with NPs or polymeric thin films and complexes
  • Investigation of sensitivity, detection limit and reusability
  • Detection of array of biomolecules

Tissue engineering. Fabrication of polymeric scaffolds for tissue engineering applications

  • Preparation of polymeric scaffolds
  • Microstructural characterization using SEM, AFM and TEM
  • Mechanical strength measurements
  • Cell-line experiments

Research Facilities Available

  • Wet chemical lab
  • UV/Visible Spectrophotometer
  • Low Temperature Incufridge
  • Low Temperature Centrifuge
  • Orbital Incubator Shaker
  • Tubular Furnace

Research Group
 

Group Leader

  • Dr. Anandhakumar Sundaramurthy

Ph.D students - 3

  • Gokul Paramasivam - Hydrogen Bonded Poly(2-oxazoline)s/Tannic Acid Multilayer Capsules for Drug Delivery Applications
  • Varsha Sharma -  Fabrication of Anisotropic Metal Nanoparticles Based Particulate Platforms for Theranostic Applications
  • Muthu P - Fabrication of Polymeric Scaffolds for Tissue Engineering Applications

M.Tech Student - 1

  • Divya Parimi - Novel Synthesis of Cerium Oxide and polyethylene glycol (PEG) NPs for drug delivery applications

B.Tech Student - 1

  • Shivani - Synthesis of Anisotropic Nanoparticles for Theranostic Applications

Alumni of Biomaterials group

  • Noufel Samed - Niosomal Drug Delivery Of Antidiabetic Drugs (M. Tech Nanotechnology, 2017) - Presently working as Trainee in Analytical Research and Development at Sami Labs Ltd., Bangalore.
  • Varsha Sharma - Cholesterol Based Niosomes for the Dual Delivery of Curcumin  and Doxorubicin Hydrochloride (M. Tech Biomedical Engineering, 2015) - Presently working as Junior Research Fellow in Our Lab.
  • Swati Jain - Electrospinning Of PCL-Chitosan Blend With Nanofillers For Effective Polymer Scaffolds in the Application of Bone Tissue Engineering (M. Tech Biomedical Engineering, 2015) -  Presently working as IT Analyst, TCS, Bangalore.
  • Thirumaran. R - Chitosan-Silver Nanoparticles Nanocomposite Scaffolds for Tissue Engineering Applications (M. Tech Biomedical Engineering, 2014) - Now started a dealership for Heart Implants (CR Biomed Devices, Madurai).
  • Nirmal. M - Hydrogen Bonded Multilayer Films for Self Healing Surface Coatings (B.Tech Nanotechnology, 2017) - Presently working on a project in our lab.
  • Jayakumar. R - Hydrogen Bonded Multilayer Films for Transdermal Drug Delivery Applications (B. Tech Nanotechnology, 2017)- Presently doing his masters program at VIT University, Vellore.

In Peer-Reviewed Journals

  • Paramasivam Gokul, Ramalingam Vinoth, Bernaurdshaw Neppolian, Sundaramurthy Anandhakumar*, “Bimetallic Nanoparticle Incorporated Composite Multilayer Thin Films for Sono-Photocatalytic Degradation of Organic Pollutants” Applied Surface Science 418 (2017) 119-127. Impact factor 3.4.
  • P. Gokul, K. Namitharan, M. R. Arul, Ashok K. Sundramoorthy, S. Anandhakumar*, “Anisotropic Noble Metal Nanoparticles: Synthesis, Surface Functionalization and Applications in Biosensing, Bioimaging, Drug Delivery and Theranostics” Acta Biomaterialia 49 (2017) 45-65.  Impact factor 6.3.
  • Pachamuthu Vanitha, S. Senthil Kumar, Sireesh Domadula, Sundaramurthy Anandhakumar, Palanisamy Rajaguru, Kunka Mohanram Ramkumar*, “Morin Activates the Nrf2-ARE Pathway and Reduces Oxidative Stress-Induced DNA Damage in Pancreatic Beta Cells” European Journal of Pharmacology 801 (2017) 9-18. Impact Factor 2.9.
  • S. Anandhakumar*, G. Krishnamoorthy, K. M. Ramkumar, Ashok M. Raichur, “Collagen Peptide Functionalized Chitosan Nanoparticles as Carriers for Encapsulation and Release of Doxorubicin for Cancer Drug Delivery” Materials Science and Engineering C 70 (2017) 378-385. Impact factor 4.2.
  • S. Chandra Kishore, S. Anandhakumar, M. Sasidharan*, “Direct Synthesis of Solid and Hollow Carbon Nanospheres Over NaCl Crystals Using Acetylene by Chemical Vapor Deposition” Applied Surface Science. 400 (2017) 90-96. Impact factor 3.4.
  • Ashok K. Sundramoorthy*, Omer Sadak, Sundaramurthy Anandhakumar, Sundaram Gunasekaran* “Synthesis of poly(8-aminopyrene-1,3,6-trisulfonic acid)/CNT Nanocomposite for Electrochemical Detection of Caffeine” Journal of The Electrochemical Society 163 (2016) B638-B643. Impact factor 3.4.
  • S. Anandhakumar*, P. Gokul, Ashok M. Raichur, “Stimuli-responsive weak polyelectrolyte multilayer films: A thin film platform for self triggered multi-drug delivery” Materials Science and Engineering C 58 (2016) 622–628. Impact Factor 4.2.
  • M. Sasidharan, S. Anandhakumar, P. Bhanja, and A. Bhaumik*, “Highly efficient colloidal Au hollow nanospheres catalyst for chemoselective oxidation of alcohols” Journal of Molecular Catalysis A 411 (2016) 87–94. Impact factor 4.0.
  • Varsha Sharma, S. Anandhakumar*, Sasidharan Manickam, “Self Degrading Niosomes for Encapsulation of Hydrophilic and Hydrophobic Drugs: An Efficient Carrier for Cancer Multi-Drug Delivery” Materials Science and Engineering C 56 (2015) 393–400. Impact Factor 4.2.
  • S. Anandhakumar, Maarten Vergaelen, Samarendra Maji, Rachel Auzély-Velty, Zhiyue Zhang, Bruno De Geest, Richard Hoogenboom*, “Hydrogen Bonded Multilayer Films based on Poly(2-oxazoline)s and Tannic Acid” Advanced Healthcare Materials 3 (12) (2014) 2040–2047. Impact Factor 5.4.
  • S. Anandhakumar*, M. Sasidharan, Cheng-Wen Tsao, A. M. Raichur “Tailor-Made Hollow Silver Nanoparticle Cages Assembled with Silver Nanoparticles: An Efficient Catalyst for Epoxidation” ACS Applied Materials and Interfaces 6(5) (2014) 3275–3281. Impact Factor 7.5.
  • J. Sripriya, S. Anandhakumar*, S. Achiraman, J. J. Antony, D. Siva, A. M. Raichur, “Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications” International Journal of Pharmaceutics 457 (2013) 206–213. Impact Factor 3.65.
  • S. Anandhakumar*, A. M. Raichur, “Silver Nanocomposite Polyelectrolyte Multilayer Films to Develop Multi-functional Thin Film Platform for Remote Activated Protein and Drug Delivery” Acta Biomaterialia 9 (2013) 8864–8874. Impact Factor 6.3.
  • S. Anandhakumar, V. Mahalakshmi, A. M. Raichur*, “Silver NPs modified Nanocapsules for Remote Activated Drug Delivery” Materials Science and Engineering C 32 (2012) 2349. Impact Factor 4.2.
  • S. Anandhakumar, S. P. Vijayalakshmi, G. Jagadeesh, A. M. Raichur*, “Silver Nanoparticle Synthesis: Novel route for Laser Triggering of Polyelectrolyte Capsules” ACS Applied Materials and Interfaces 3(9) (2011) 3419. Impact Factor 7.5.
  • S. Anandhakumar, A. M. Raichur*, “A facile route to synthesize silver nanoparticles in polyelectrolyte capsules” Colloids and Surfaces B: Biointerfaces 84 (2011) 379. Impact Factor 3.9.
  • S. Anandhakumar, M. Debapriya, V. Nagaraja, A. M. Raichur*, “Polyelectrolyte microcapsules for sustained delivery of water-soluble drugs” Materials Science and Engineering C 31 (2010) 342. Impact Factor 4.2.
  • S. Anandhakumar, V. Nagaraja, A. M. Raichur*, “Reversible polyelectrolyte capsules as carriers for protein delivery” Colloids and Surfaces B: Biointerfaces 78 (2010) 266. Impact Factor 3.9.

 

In Proceedings/Book chapters

  • S. Anandhakumar, “Responsive polyelectrolyte multilayer nanofilms for drug delivery applications” Book chapter in “Recent Trends in Designing Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications”, Vol. 1: Types & Triggering Mechanisms of Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery (Abdel Salam Hamdy Makhlouf, Nedal Y. Abu-Thabit Eds.)” Elsevier publisher, Expected date of publishing: November 2017 (Accepted).
  • P. Gokul, Varsha Sharma, S. Anandhakumar*, “Polyelectrolyte Multilayer Film Coated Silver Nanorods: An Effective Carrier System for Externally Activated Drug Delivery” IOP: Materials Science and Engineering. Accepted.
  • M. Sasidharan, S. Anandhakumar, S. Vivekananthan, “Polymeric Nanomaterials: Applications in Theranostics” Book chapter in “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials”. (DOI: 10.1081/E-EBPP-120050397; Taylor & Francis Publishers, 2014)
  • S. Anandhakumar, Ashok M. Raichur, “PSS-doped Nanostructured Polyelectrolyte Capsules for Delivery of Proteins” Abstracts of papers-American Chemical Society, National Meeting, American Chemical Society, 242 (2011).

Conference Presentations

  • Gokul Paramasivam, Maarten Vergaelen, Richard Hoogenboom, Anandhakumar Sundaramurthy*, “Temperature Responsive Hydrogen Bonded Tannic Acid/Poly(2-n-proply-2-oxazoline) Capsules for Drug Delivery Applications” Macro-2017, Trivandrum, India, January 8-11, 2017.
  • P. Gokul, Varsha Sharma, S. Anandhakumar*, “Polyelectrolyte Multilayer Film Coated Silver Nanorods: An Effective Carrier System for Externally Activated Drug Delivery” ICAMT, Andhra pradesh, India, December 27&28, 2016.
  • P. Gokul, S. Anandhakumar, “Soft Template Assisted Synthesis of Silver Nanorods: An Effective Nanoparticle System for Externally Activated Drug Delivery” Research Day, SRM University, Chennai, India, Feb 27, 2015. (Secured Gold medal).
  • Sripriya, S. Anandhakumar, “Laser Receptive Polyelectrolyte Thin Films Doped with Biosynthesized Silver Nanoparticles for Antibacterial Coatings and Drug Delivery Applications” Research Day, SRM University, Chennai, India, Feb 28, 2014. (Secured Gold Medal).
  • S. Anandhakumar, Ashok M. Raichur, “Silver Nanocomposite Polyelectrolyte Multilayer Films as Multifunctional Thin Film Platforms for Externally Activated Protein and Drug Delivery” Third Euro-India International Conference on Nanomedicine and Tissue Engineering, Kottayam, India, August 9-11, 2013.
  • S. Anandhakumar, Ashok M. Raichur, “Silver Nanocomposite Polyelectrolyte Multilayer Films for Remote Activated Protein and Drug Delivery” National Conference on Hierarchically Structured Materials” Chennai, India, January 24-25, 2013.
  • S. Anandhakumar, V. Mahalakshmi, A. M. Raichur, “Silver Nanocomposite Polyelectrolyte Multilayers for Remote Activated Drug delivery” International Conference on Nanotechnology at the Bio-Medical Interface, Kochi, India, Feb 21-23, 2012.
  • S. Anandhakumar, and A. M. Raichur, “PSS-doped Nanostructured Polyelectrolyte Capsules for Delivery of Proteins” Symposium: Nanomedicine - Surface and Colloid Science, ACS Annual Meeting, Denver, CO, USA, Aug 28 - Sept 1, 2011.
  • S. Anandhakumar, A. M. Raichur, “ In-situ Synthesis of Silver Nanoparticles in Polyelectrolyte Capsules for Laser Activated Drug Delivery” International Conference on Materials for Advanced Technologies (ICMAT), Singapore, June 25-July 1, 2011.
  • A. M. Raichur, D. Neela Priya and S. Anandhakumar, “Inorganic/Organic Hybrid Films for Environmental Applications,” Slovenia-Italian Conference on Materials and Technologies for Sustainable Growth, Ajdovščina, Slovenia, 4-6 May, 2011.
  • S. Anandhakumar, A. M. Raichur, “Synthesis and Applications of Stimuli Responsive Nanostructured Polyelectrolyte Films and Capsules,” Polymer Science and Engineering - 2010, Chandigarh, India, 25-26 November, 2010.
  • S. Anandhakumar, A.M. Raichur, “Smart Polyelectrolyte Capsules as Carriers for Drug Delivery Applications” World Conference on Nanomedicine and Drug Delivery, Kottayam, India, 16-18 April, 2010.
     

2013 Odd semester

  • BM0685 Drug Delivery Systems

2014 Odd semester

  • BM0685 Drug Delivery Systems

2015 Odd semester

  • NT1014 Nanobiotechnology

2016 Odd semester

  • NT1014 Nanobiotechnology

2017 Odd semester

  • 15NT303 Nanobiotechnology

Postdoctoral positions

  • One post doctoral position is available now.

Ph.D Students

  • None at this time

M.Tech/M.Sc and B. Tech students

  • Two positions are available now. Interested students can contact me directly.

Project Assistants

  • Will be updated soon

Contact:

Dr. Anandhakumar Sundaramurthy,
Research Assistant Professor,
Research Institute & Department of Physics and Nanotechnology,
Room No-2, 13th floor, Central Library Building,
SRM University, Kattankulathur- 603203
Email: anandhakumar.s@res.srmuniv.ac.in 
Phone: 04427417902